Multifarious Transcriptional Regulation by Myb2 Protein in Trichomonuras Vaginalis |
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Myb2 protein is a novel protein in the Protozoan Parasite Trichomonas vaginalis that causes the most sexually transmitted disease of nonviral origin in humans. Cytoadherence, which is crucial for T. vaginalis to establish an infection, has been shown to involve multiple surface adhesion proteins (ap) and lipophosphoglycans. T. vaginalis, is critically regulated by the coordination of two similiar but opposite oriented DNA regulatory regions, MRE-1/MRE-2r and MRE-2f, both of which are binding sites for multiple Myb-like proteins. Myb2 is involved in activation of both iron-inducible and growth-related transcriptionn of the ap65-1 gene. On the scale of the biological molecular structure, we want to understand that the transcription of the ap65-1 gene is regulated by coordination or competition of multiple Myb proteins to gain access to the MRE-1/MRE-2r and MRE-2f sites.
