Nuclear Magnetic Resonance ( NMR ) is a powerful and sophisticated biophysical technique with broad applications in many disciplines.
The High Field Nuclear Magnetic Resonance Center ( HFNMRC ) was first established in 2002 by Dr.Tai-huang Huang, under the support from National Research Program for Genomic Medicine, to meet the challenging needs in structure-functional characterization of proteins and other macromolecules in the post-genomic era. Since 2015, HFNMRC become one of the core facilities under Division of Instrument Center in Academia Sinica. It is our goal to make this a truly world-class national high-field NMR facility to support and promote structural genomics, structural biology and pharmaceutically related research and developmental activities in Taiwan in general.
The thrusts of NMR spectroscopy are:
- It is the only method for determining macromolecular structure in near physiological conditions.
- It is the best method for determining molecular dynamics over broad time scale in atomic details.
- It is a powerful and efficient method for determining molecular interactions.
- It is a powerful method for probing macromolecular folding and disordered states.
- It is a rapid and efficient method for screening drugs and small ligands that interact with macromolecules and receptors.
Currently, HFNMRC operates and maintains six state-of-the-art NMR spectrometers:
- One 500 MHz equipped with TXI / QNP cryoprobe
- Three 600 MHz , one with TXI cryoprobe, one with TCI cryprobe
- One 800 MHz equipped with TXI cryoprobe
- One 850 MHz equipped with TCI cryoprobe